When proteases, CEA and CA 19-9 were used as single markers, considering the above mentioned optimal cut-off values, sensitivity of PAI-1 (94%), CATB (82%), uPA (69%) and CATL (41%) were more indicative for CRC than CEA or CA 19-9 (30% and 18%, respectively). Here, CEACAM5 is linked to colorectal carcinoma.