The association of proteolytic enzymes and CEA, CEA-19 and survival was tested using their median values in the group of CRC (CATB: 8.75 ng/ml; CATL: 1.1 ng/ml; uPA: 0.29 ng/ml; PAI-1: 52.45 ng/ml; CEA: 2.40 ng/ml; CA 19-9: 9.15 ng/ml). This evidence concerns the gene PLAU and colorectal carcinoma.