CD4 and granular corneal dystrophy type II: ACD is a major occupational and environmental dermatological health problem, often causing work disability due to occupational exposure to contact allergens (haptens).1 The inflammatory infiltrate in ACD is composed of CD8+ and CD4+ T cells, dendritic cells (DCs), eosinophils, monocytes and an early and transient presence of neutrophils.2–5 Cytokines produced by T-helper (Th) 1 and Th2 type cells are involved in the expression of contact hypersensitivity (CHS).2,3,6,7