SCN5A and familial long QT syndrome: Thus insertion of aspartate (1795insD) in the carboxy terminus of SCN5A can result in either BrS or LQTS (Bezzina et al. 1999, Veldkamp et al. 2000), and mutation of the same residue to a histidine (Y1795H) or cysteine (Y1795C) also results in BrS and LQTS respectively.