Taken together withthese considerations, as PPARγ ligands are probably effective in the suppressionof tumor development, especially on the reduction of tumor invasiveness throughmolecular signals from adipocytes, thiazolidinedione should be chosen not only for diabetic control, butalso as an attenuator of tumor progression in patients with diabetes.Drug-induced hepatitis can be avoided by meticulous monitoring of serum hepaticenzyme levels. This evidence concerns the gene PPARG and diabetes mellitus.