PPARD and colonic neoplasm: Several experimental resultsindicate that ligand activation of PPARβ/δ induces terminal differentiation ofkeratinocytes [86, 87, 95, 96] and it has also been shown that differentiationof breast and colon cancer cell lines is associated with increased expressionof PPARβ/δ [97].PPARβ/δ expression also increases following differentiation inhuman primary macrophages or in monocyte/macrophage cell lines [98].