In conclusion, the result showing that PPARγ activation upregulates PTEN,which has also been implicated in tumor-inhibitory or anti-inflammatory actionsof PPARγ [106, 115], gives credence tothe concept that PPARγ activators induce PTEN duringS6K1 inhibition, and consequently causes TGFβ1 repression. Here, TGFB1 is linked to neoplasm.