As well, glioblastoma and neuroblastoma cells can besensitized to TRAIL-induced apoptosis by troglitazone [51].In addition to upregulation of DR5 and reduction of c-FLIP, troglitazonedownregulated survivin levels in these cells, all of which may explain thesynergy observed with troglitazone and TRAIL treatment. This evidence concerns the gene TNFSF10 and neuroblastoma.