Importantly, cyclinD3 downregulation is associated with troglitazone-induced survivin reductionand enhancement of TRAIL-induced apoptosis in human breast cancer cells assilencing of cyclin D3 reduced the levels of survivin and promotedTRAIL-induced apoptosis [48].Currently, it is unclear how cyclin D3 regulates survivin expression. Here, BIRC5 is linked to breast carcinoma.