As well, rosiglitazonesensitized the breast cancer cell line, MDA-MB-231, to the antitumor effects ofCH11 as well as TNF-α [62].In uterine leiomyoma cells, ciglitazone downregulated the antiapoptotic proteinBcl-2 and upregulated Bax and Fas while enhancing PARP cleavage and caspase-8activation, suggesting that ciglitazone induces apoptosis in a Fas- andcaspase-dependent mechanism [63]. This evidence concerns the gene FAS and Uterine leiomyoma.