Proline oxidase (POX) is a redox enzyme localized inthe mitochondrial inner membrane and functions as a p53-induced gene that canmediate apoptosis through generation of reactive oxygen species (ROS) [17].A recent study in colon cancer cells showed that troglitazone enhanced thebinding of PPARγ to PPRE in the POX promoter, activatedthe POX promoter, and increased endogenous POX expression. Here, PRODH is linked to malignant colon neoplasm.