The combination of MK886with 15d-PGJ2 generated greater growth-inhibitory effects includingapoptosis than each single agent alone in A549 lung cancer cells [54].Moreover, MK866 increased the expression of RXRα whose heterodimerization with PPARγ is thought to be necessary for theproapoptotic effect of PPARγ. The gene discussed is PPARG; the disease is lung carcinoma.