When RS5444 was combined withpaclitaxel, a standard treatment for anaplastic thyroid cancer, enhancedapoptosis-inducing effects were observed [59].Similarly, the combination of a PPARγ agonist and docetaxel also exertedenhanced apoptosis-inducing and antitumor effects in human lung cancer cells.In addition, 15d-PGJ2 combined with docetaxel significantly reducedtumor volume compared with control, 15d-PGJ2, or docetaxel alone inboth A549 and H460 xenografts. The gene discussed is PPARG; the disease is lung carcinoma.