PRODH and colonic neoplasm: Proline oxidase (POX) is a redox enzyme localized inthe mitochondrial inner membrane and functions as a p53-induced gene that canmediate apoptosis through generation of reactive oxygen species (ROS) [17].A recent study in colon cancer cells showed that troglitazone enhanced thebinding of PPARγ to PPRE in the POX promoter, activatedthe POX promoter, and increased endogenous POX expression.