Furthermore, the PPARγ antagonists stronglyinhibited the invasion of squamous cell carcinomas.These resultsimply a potentially important and novel role for the inhibition ofPPARγ function via the use of specificantagonists in the treatment of oral squamous cell carcinoma and theprevention of tumor invasion and metastasis [69].Similarly, these antagonists also induced apoptosis in colorectal cancer cellsas well as altered cell morphology which was linked to alterations inmicrotubules. Here, PPARG is linked to neoplasm.