The role of PPAR-γ in modulating AD is supported bystudies indicating that ibuprofen reduced Aβ1−42 levels in APPtransgenic mouse models of AD, while low levels of the thiazolidinedionepioglitazone stimulated a slight yet statistically insignificant reduction ofAβ1−42 levels in these mice [49]. The gene discussed is PPARG; the disease is Alzheimer disease.