In addition, ithas been shown in pancreatic cancer cells that 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide(CDDO-Im), a partial PPAR-γ agonist, induces apoptosis directly bytargeting mitochondrial glutathione [38]. The gene discussed is PPARG; the disease is familial pancreatic carcinoma.