15-deoxy-Δ12,14-prostaglandin J2 (15-PGJ2),a nonenzymatically formed dehydration product of PGD2, is detectablein COX-2 expressing human pancreatic cancer cells (own observation) and able toactivate PPAR-γ in these cells [42]. This evidence concerns the gene PPARG and familial pancreatic carcinoma.