PPARG and cancer: In addition to the effects of PPAR-γ ligands on the growth of establishedpancreatic cancers in preclinical cell culture and xenograft mouse models,dietary intake of 800 ppm pioglitazone for 22 weeks correlated with an improvedserum lipid profile and a decreased incidence and multiplicity of pancreatictumors in the N-nitrosobis(2-oxopropyl)amine (BOP) model of pancreaticcarcinogenesis in Syrian golden hamsters, suggesting a potentialchemopreventive role of TZDs [45].