Although the role of PPAR-γ in pancreatic cancer development and growthhas begun to be elucidated in recent years, a precise knowledge of moleculartargets downstream of PPAR-γ, a more comprehensive elucidation of PPAR-γ-independent actions of PPAR-γ ligands, and a detailed understanding ofcrosstalks between PPAR-γ and other intracellular signaling pathwaysseem to be absolutely necessary and needed to eventually clarify the role ofPPAR-γ in human cancer development and progression. The gene discussed is PPARG; the disease is cancer.