B7-H3, the antigen recognized by the 5B14 mAb, has been shown to downregulate NK- and/or T-mediated antitumour activity by interacting with a putative inhibitory receptor.9 Based on the great heterogeneity of 5B14 reactivity in NB tumours, we sought to perform NB patients’ survival analysis by stratifying them according to the 5B14 positivity in their tumours. This evidence concerns the gene CD276 and neuroblastoma.