On the other hand, functional data suggest that T and natural killer (NK) lymphocytes express specific receptor(s) displaying either an inhibitory or co-stimulatory function.11,12 In particular, B7-H3 expressed at the tumour cell surface exerts a protective role in NK-mediated lysis.9 Notably, the mAb selectively stains NB cells infiltrating the bone marrow of stage 4 patients.13 The gene discussed is CD276; the disease is neoplasm.