TCF4 and neoplasm: Taken one by one, we observed a significant or nearly significant decay of only some mutant mRNAs compared to wild-types and this is not surprising since: (i) as recently published by our group, NMD impact on the expression of frameshift mutation-derived mRNAs is highly variable from one mutant to another [14]; (ii) frequencies of target gene alterations were highly variable and sometimes very low in our tumor series; (iii) some mutants in particular (TCF4) are NMD-irrelevant.