The decay of mutant mRNAs compared to wild-types was significant for MSH6 (P = 0.02; Student's t-test) and nearly significant for a few others only, e.g. BAX (P = 0.08), CDX2 (P = 0.10), MSH3 (P = 0.10), RIZ (P = 0.10) and TFDP2 (P = 0.10), providing evidence for differential decay of PTC-mRNAs compared to wild-type in our series of primary CRCs, as already described in a series of MSI CRC cell lines [14] (Figure 3). This evidence concerns the gene MSH3 and colorectal carcinoma.