Our next plan is to examine changes in the signal transduction molecules related with the BCR-ABL1 pathway such as CrkL, Ras, Jak2, Stat5, and c-Myc [26] as well as molecules that are not linked with BCR-ABL1 pathway including Lyn [30] in both AQP5-overexpressing and AQP5-silenced CML cell lines. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.