When the mutant and wildtype transgenes were introduced into Tnnt2+/− to generate Tnnt2+/−/TGK210Δ and Tnnt2+/−/TGWT mice, the Tnnt2+/−/TGK210Δ mice recapitulated severe DCM features observed in humans with the K210Δ mutation [2]. This evidence concerns the gene TNNT2 and familial dilated cardiomyopathy.