Interestingly, three other gross deletions at the CDKN2A locus, impacting on both p16 and p14, have been reported from melanoma-NST families (Bahuau et al, 1998; Randerson-Moor et al, 2001; Mistry et al, 2005; Pasmant et al, 2007), and a splice site mutation removing CDKN2A exon 2 was also found in a melanoma/neurofibroma family (Petronzelli et al, 2001). Here, CDKN2A is linked to melanoma.