CDKN2A and melanoma: The question of whether or not large genomic deletions, undetectable by traditional PCR-amplification and sequencing of individual exons, may be the cause of such unexplained familial clustering of melanoma has been raised, and few authors have searched for large CDKN2A/ARF deletions or rearrangements (Fitzgerald et al, 1996; Bahuau et al, 1998; Randerson-Moor et al, 2001; Debniak et al, 2004; Mistry et al, 2005; Knappskog et al, 2006, Erlandson et al, 2007).