CDKN2A and melanoma: We chose to apply MLPA analysis to determine whether large deletions or rearrangements occur at the CDKN2A/ARF locus on 9p21 in French CMM families; however, the failure to detect large deletions using this technique does not exclude the possibility that large deletions may exist, as the probes used do not cover the entire genomic sequence of CDKN2A. Moreover, neither inversions, nor translocations are detectable by this approach, and such genomic alterations cannot be ruled out in melanoma families where no CDKN2A mutation has been detected.