Large deletions have also been found in families with combined proneness to melanoma and nervous system tumours (NST): a gross deletion ablating the whole CDKN2A and CDKN2B genes has been reported in a French family (Bahuau et al, 1998; Pasmant et al, 2007), and a deletion of p14ARF-specific exon 1β of the CDKN2A gene has been found in one US family and in two UK families (Bahuau et al, 1998; Randerson-Moor et al, 2001; Mistry et al, 2005; Laud et al, 2006). This evidence concerns the gene CDKN2A and nervous system neoplasm.