Top-scoring genes are mainly involved in RNA processing (CSTF2, SNRPA, SNRPA1, SNRPE, USP39, HNRPAB), which could either be a secondary effect of proliferation or reflect the increased metabolic activity of cancer cells, and chromatin remodeling (ACTL6A, SMARCC1), indicating that epigenetic mechanisms may be involved in the maintenance of an embryonic phenotype in many cancers. This evidence concerns the gene USP39 and cancer.