In order to characterize the effects of different antidepressants on total human BDNF mRNA expression, SH-SY5Y neuroblastoma cells were treated with FLX, RBX or DMI for 6 h (to assess the effects of short-term treatments), 24 or 48 hours, as in recent studies assessing the long-term effects of antidepressants in cultured cells [16,17]. This evidence concerns the gene BDNF and neuroblastoma.