Insulin-like growth factor 1 (IGF-1), via binding to the IGF-1 receptor (IGF-1R), is thought to contribute to the development of prostate cancer by promoting proliferation and blocking apoptosis [1,2], which likely account for the epidemiological findings of association between IGF-1 or elements of its regulatory system and the development of prostate cancer [3]. This evidence concerns the gene IGF1R and Familial prostate cancer.