Two of these SNPs belong to highly replicated biological candidate genes PPARG2 (Pro12Ala; rs 1801282) and KCNJ11 (Glu23Lys; rs 5219) that produced unequivocal evidence of their involvement in T2D in several independent studies performed in different data sets [22,23]. This evidence concerns the gene PPARG and type 2 diabetes mellitus.