We have identified a significant association of PPARG2 (rs1801282; p = 0.005), IGF2BP2 (rs 4402960; p = 0.027) and FTO (rs 9939609; p = 0.007) variants with T2D along with the TCF7L2 variant (rs10885409; p = 0.001) in our Asian Indian population. This evidence concerns the gene IGF2BP2 and type 2 diabetes mellitus.