In this setting, the immune system mounts a robust anti-HIV T cells immune response that decreases significantly the acute plasma viremia to a lower set point; however, shortly after the primary infection, the T cell-mediated immune pressure generates escape mutants that mediate new rounds of infection that result in increased virus spreading and further deletion of CD4+ susceptible cells [11-14] (shown in Figure 1, 2). Here, CD4 is linked to infection.