Several studies have demonstrated that the activities of 5-FU metabolizing enzymes such as TS, DPD and OPRT predict the efficacy of chemotherapy with 5-FU for unresectable metastatic colorectal cancer[6,7]; however, few reports have investigated the relationship between the activity of these enzymes and duration survival in patients with colorectal carcinoma receiving radical operation combined with adjuvant oral 5-FU chemotherapy[8,9]. Here, TYMS is linked to colorectal carcinoma.