Here we have shown that while ectopic expression of PPARγ2 is able to induce final adipogenesis of primary fibroblasts expressing FUS-DDIT3, C/EBPα is unable to rescue the impaired adipogenesis of adipocytic precursors expressing FUS-DDIT3, suggesting that the down-regulation of PPARγ2 by FUS-DDIT3 is one of the critical steps in the blockade of adipocyte differentiation in liposarcomas. The gene discussed is PPARG; the disease is liposarcoma.