FUS and liposarcoma: Next, we examined whether this upregulation of eIF4E was a direct effect of FUS-DDIT3, or a consequence of the blockade in adipocyte differentiation in liposarcomas, as it has been previously shown that knock out mice for 4E-BP1, a protein that represses cap-dependent translation initiation by sequestering eIF4E, evidenced reduced WAT mass [39].