Thus and with the aim of clarifying the relationship between the PPARγ and C/EBPα pathways in liposarcomas, we next assessed the role of the C/EBPα downregulation in the process of adipogenesis in FUS-DDIT3 MEFs, as these MEFs show a dramatic downregulation and inactivation of PPARγ (Figure 1B). The gene discussed is FUS; the disease is liposarcoma.