TNC and neoplasm: Moreover, the increased expression of collagen V–a collagen type that has been shown to accumulate in malignant disease [40]–and the more diffuse distribution of Tenascin C–an ECM protein that is overexpressed in pancreatic cancer [41]–and of αSMA in AIPC compared to CP may account for the radiological and macroscopic tumor-like appearance of AIPC.