An additional level of crosstalkis constituted by the fact that PPARγ cofactors, such as steroid receptor coactivator (SRC) family members(e.g., AIB/SRC3 in breast cancer), are phosphorylated by MAPKs and thereby arealtered in their ability to coactivate transcription [47](Figure 1(c)). The gene discussed is PPARG; the disease is breast carcinoma.