To comprehensively examine the role of common genetic variation in the IGF1, IGFBP1, and IGFBP3 genes in relation to circulating IGF-I and IGFBP-3 levels and breast cancer risk, we conducted a haplotype-based analysis in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3) [13]. This evidence concerns the gene IGFBP3 and Familial prostate cancer.