None of the IGF1 and IGFBP3 SNPs associated with circulating IGF-I and IGFBP-3 levels were significantly associated with breast cancer risk (Tables 3 and 4 for IGF1 and IGFBP1/3, respectively), nor were other SNPs or haplotypes consistently associated with risk. Here, IGFBP3 is linked to breast carcinoma.