The multivariate analysis also showed that low expression of ERCC1 (HR 0.120; 95% CI, 0.016–0.934%) (P=0.043) together with tumours other than oral cavity primary tumours (HR 0.168; 95% CI, 0.040–0.707) (P=0.015), and stage III tumours (HR 0.081; 95% CI, 0.009–0.716) (P=0.024) were independent predictors of the prolongation of OS (Table 4). This evidence concerns the gene ERCC1 and neoplasm.