Although the association between ERCC1 expression and clinical outcomes in patients with SCCHN treated with radiotherapy has not been established, in NSCLC, the level of induced DNA adducts in buccal cells is strongly associated with outcome after definitive concomitant low-dose cisplatin and radiotherapy for stage IIIA/B NSCLC (van de Vaart et al, 2000). The gene discussed is ERCC1; the disease is non-small cell lung carcinoma.