Previous reports have shown that the stimulation of this receptor augments VEGF expression in various tumoral and non-tumoral tissues and that its blockage inhibits VEGF expression in gliomas and other tissues (Chua et al, 1998; Tamarat et al, 2002; Arrieta et al, 2005; Imai et al, 2007). The gene discussed is VEGFA; the disease is central nervous system cancer.