DLEC1 and neoplasm: Further analysis led to the identification of the DLC1 gene (Daigo et al, 1999), which was later renamed DLEC1. Loss of DLEC1 expression has been observed in lung, oesophageal, renal, ovarian and nasopharyngeal carcinoma cell lines and primary tumours and functional analyses strongly suggest that DLEC1 is a tumour suppressor gene (Daigo et al, 1999; Kwong et al, 2006, 2007).