Expression of inhibitors such as PKCε (Shinohara et al, 2001), cFLIP (Hao et al, 2001; Xiao et al, 2002) or PEA-15 (Hao et al, 2001; Xiao et al, 2002) was associated with resistance in a small number of glioma cell lines, but causal relationships were not conclusively demonstrated. This evidence concerns the gene CFLAR and central nervous system cancer.