Some resistant glioma cell lines could be sensitised by the treatment with the translation inhibitor cycloheximide, implicating a labile inhibitor of TRAIL signalling in the resistance of those cell lines (Rieger et al, 1998; Wu et al, 2000; Hao et al, 2001; Rohn et al, 2001; Fulda et al, 2002a). This evidence concerns the gene TNFSF10 and central nervous system cancer.