A few papers have documented the TRAIL responsiveness of minimally cultured gliomas, most of which were resistant to TRAIL as a sole agent (Roa et al, 2003; Song et al, 2003; Jeremias et al, 2004; Eramo et al, 2005; Li et al, 2006; Koschny et al, 2007). The gene discussed is TNFSF10; the disease is glioma.