We also report a strategy to inhibit MnSOD and increase O2•− generation in ovarian cancer cells as a novel mechanism to enhance apoptosis induced by doxorubicin (DOX) and paclitaxel (PTX), the two front-line anti-cancer agents used in ovarian cancer therapy, leading to a preferential killing of the cancer cells. The gene discussed is SOD2; the disease is ovarian carcinoma.