SOD2 and ovarian carcinoma: We and others have observed that ovarian carcinomas constitutively overexpress MnSOD compared with normal cells and tissues, and increased MnSOD has been detected in ∼70% of malignant ovarian cancer tissues (Ishikawa et al, 1990; Hileman et al, 2004; Hu et al, 2005), although there was some variations among the individual samples.