Specifically, the invasiveness of ameloblastoma cells after transfection with 1, 2 or 3 μg of pRNA-MMP-2 was decreased by 15.3, 55.5, and 61.3%, respectively, and 24.2, 53.3, and 50.5% in cells transfected with pcDNA-TIMP-2, respectively. Here, MMP2 is linked to ameloblastoma.