Parameters of geohelminth infection were strongly positively associated with fold-increased levels (OR>1) of total IgE in all models: a) any geohelminth parasite (Model 1, P < 0.001; Model 4, P = 0.001); b) infections with T. trichiura (Model 2, P < 0.001); c) increasing infection intensities with T. trichiura (Model 3, test for trend across tertiles, P < 0.001); and d) increasing levels of anti-A. The gene discussed is IGHE; the disease is infection.