We and others have previously shown that a region of chromosome 19q13.3 seems associated with a number of cancers, including cancer of the skin, breast, lung and brain [1-12], but not testis and colorectal cancer [13,14] Central in this chromosomal region is a 69 kb stretch, which contains two genes of importance for DNA repair, XPD (also known as ERCC2) and ERCC1, one gene presumably relating to apoptosis, RAI (also known as iASPP or PPP1R13L), and one presumably involved in ribosomal RNA transcription, ASE1 alias CD3EAP (see Figure 1). The gene discussed is PPP1R13L; the disease is colorectal cancer.