Our observation is in line with putative role of TLR4 receptors in the developmentof inflammatory responses in rheumatoid arthritis, suggesting that even inpatients with newly detected and not yet pharmacologically treated RA, circulatinginflammatory cells (monocytes) can be easily triggered via TLR4 stimulation togenerate proinflammatory cytokines. This evidence concerns the gene TLR4 and rheumatoid arthritis.