TLR4 and rheumatoid arthritis: Recent studies describedhigher expression of TLR4 in leucocytes frompatients with ankylosing spondylitis and increased expression of TLR2 and TLR4receptors in cartilage lesions occurring during OA suggesting that abnormal TLRsignaling may also be involved in thepathogenesis of rheumatologic conditions other than rheumatoid arthritis [11, 12].