Plasma A-SAA was elevated in the 1 w HFD group (seeFigure 1; 5.06 ± 1.05 μg/mL versus 2.11 ± 0.25 μg/mL in control animals, P < 0.05)and increased substantially further in the 16 w HFD group (31.4 ± 7.0 μg/mL, P < .01 versus controls),demonstrating that the plasma levels of A-SAA are associated with obesity andinsulin resistance in a quantitative fashion. Here, SAA2 is linked to obesity due to melanocortin 4 receptor deficiency.