PPARD and colorectal cancer: Moreover, since both the introduction of the knockoutmutation of the COX-2 gene into ApcΔ716 mice, a model of humanFAP, and treating ApcΔ716 mice with NSAIDs reducethe development of intestinal tumors, COX-2 inhibitors have been considered astherapeutic agents for colorectal polyposis and cancer [95].He et al. reported that NSAIDs inhibitedthe transcriptional activity of PPARδ by disruption of the DNA bindingability of PPARδ/RXR heterodimers, and ectopicexpression of PPARδ in the human colorectal cancer cellline, HCT116, protected the cells from sulindac-induced apoptosis [77].