Refaeli et al. also noted that tumour cells from either EμMYC/BCRHEL/sHEL or MMTV-rtTA/TRE-MYC/BCRHEL/sHEL mice generated lethal tumours in recipients that did not express the HEL antigen, but this was attributed to the expression of the HEL transgene by the transplanted tumour cells. This evidence concerns the gene MYC and neoplasm.