If BCR signalling is truly crucial for the formation of tumours in EμMYC/BCRHEL, EμMYC/BCRHEL/sHEL, and MMTV-rtTA/TRE-MYC/BCRHEL/sHEL mice, then these lymphomas should be sensitive to immunosuppressive drugs that block the BCR signalling pathway at particular points. The gene discussed is BCR; the disease is lymphoma.