Third, the sequences for the immunoglobulin molecules in many NHL, including BL, bear somatic mutations of the sort that normally arise during the process of affinity maturation [8–14] If antigenic stimulation does play a role in the genesis of human BL, it would be in cooperation with MYC, whose activation by chromosomal translocation is a general feature of the tumor [87]. This evidence concerns the gene MYC and non-Hodgkin lymphoma.