PRRT2 and neoplasm: Concerning the Wnt signalling cascade, the binding of one among the 19 known extracellular soluble secreted Wnt ligands (WNT) to one or more among the 10 Frizzled receptors (FZD) in cooperation or not with LRP coreceptors (low-density lipoprotein receptor (LDLR)-related protein), LRP-5 or LRP-6, can differentially lead to the activation of either the canonical β-catenin, or the noncanonical c-Jun N-terminal kinase (JNK) and protein kinase C (PKC) pathways, which may control the tumour phenotype.