In parallel, recent progress has been achieved in understanding the essential role and function that represents dysregulation of pleiotropic growth factors – that is, the insulin-like growth factor-II (IGF-II), hepatocyte growth factor (HGF), transforming growth factor-α (TGF-α), transforming growth factor-β (TGF-β), and wingless (Wnt) – in contributing to proliferation and antiapoptotic behaviour of HCC cells (Breuhahn et al, 2006). Here, IGF2 is linked to hepatocellular carcinoma.