Finally, we have observed that at least one over the three known different intracellular pathways potentially controlled by the WNT/FZD signalling during embryogenesis or carcinogenesis – that is, canonical β-catenin, or noncanonical PKC and JNK – appeared activated in a majority of the tested HCC tissues containing the accumulation of WNT/FZD element dysregulations. This evidence concerns the gene MAPK8 and hepatocellular carcinoma.