Noticeably, FZD3, and FZD7 were found more closely related to the poorly differentiation status of tumours, indicating their possible involvement in the latter steps of hepatocarcinogenesis, and their possible role in the metastasis processes and epithelial-mesenchymal transition as recently reported for FZD7 in colon tumours (Vincan et al, 2005). Here, FZD7 is linked to neoplasm.