Concerning relationship to aetiologic factors of HCC, with the notable exception of FZD7 which showed higher rate of upregulation in HBVvs non-HBV-related HCC (59 vs 23%, CHI-2 test, P=0.035), WNT3/4/5A, FZD3/6, and sFRP1/5 were statistically equally dysregulated between HBV, HCV, and NBNC-related HCCs. This evidence concerns the gene SFRP1 and hepatocellular carcinoma.