Finally, as the WNT/FZD/sFRP signalling elements are dysregulated in most HCCs, we have been unable to find a specific association between their expression pattern and the occurrence of either TP53 or β-catenin gene mutations, which paradoxically had been shown in previous studies as dichotomizing HCC tumours in different clusters (Laurent-Puig et al, 2001). This evidence concerns the gene TP53 and hepatocellular carcinoma.