TP53 and hepatocellular carcinoma: In parallel, we have shown that the WNT/FZD/sFRP expression patterns did not correlate to the TP53 and β-catenin gene mutation status in the HCC samples, these genes being the most frequently altered tumour suppressor and proto-oncogene in HCC (Laurent-Puig and Zucman-Rossi, 2006).