BIRC5 and non-small cell lung carcinoma: In the study conducted by Morgillo et al (2007) only the treatment with gefitinib, an EGFR-TKI, but not cetuximab, induced EGFR-IGF1R heterodimerisation and activation of IGF1R and its downstream signalling mediators, resulting in increased survivin expression in NSCLC cell lines with high levels of IGF1R expression.