In the study conducted by Morgillo et al (2007) only the treatment with gefitinib, an EGFR-TKI, but not cetuximab, induced EGFR-IGF1R heterodimerisation and activation of IGF1R and its downstream signalling mediators, resulting in increased survivin expression in NSCLC cell lines with high levels of IGF1R expression. This evidence concerns the gene EGFR and non-small cell lung carcinoma.