BRCA2 and Familial prostate cancer: Moro et al (2008) show that downregulation of BRCA2 expression through the introduction of siRNA in prostate cancer cells promoted cancer cell migration and invasion. Mitra et al (2008) found the average grade of prostate cancers among men with BRCA2-associated prostate cancers (Gleason score) to be higher than that of noncarrier control tumours.