Published work on lymphangiogenesis in pancreatic cancer has identified VEGF-C and VEGF-D as important stimulators (Tang et al, 2001; von Marschall et al, 2005) prompting us to test the effects of p16 induction on the amount of VEGF-C or -D produced in MiaPaca-2-TREx-p16 cells in vitro. This evidence concerns the gene VEGFD and pancreatic neoplasm.