There could be other genes and pathways that are activated by PHI-induced hypomethylation, because hypermethylation of tumor suppressor genes, such as SOCS-1, p16, E-cadherin, DAP kinase, MGMT, were frequently detected in myeloma cell lines as well as in clinical specimens from patients with plasma cell disorders [4,7]. This evidence concerns the gene SOCS1 and plasma cell neoplasm.