These trinucleotides are neither related to the AID targeting (WRC/GYW) (W, A or T; R, A or G; Y, C or T) motifs, nor the SHM hotspot motifs (RGYW/WRCY), and no difference in targeting of the A residues within these motifs could be observed between ATLD patients and controls (Table 2 and Table S3). This evidence concerns the gene AICDA and ataxia-telangiectasia-like disorder.