Despite polycistronic transcription, a priori there is no compelling reason to assume that turnover of mRNA is uncoupled from signaling systems and, moreover, the observation that iron-deficiency leads to increased expression of the ESAG6/7 transferrin receptor mRNAs and protein provides a potential example of signal-mediated changes to mRNA abundance  [45,65,105]. Here, TFRC is linked to Iron deficiency anemia.