Hypothetically this could provide some advantages, i.e.: i) in case immune response to tumor antigens is possible, some of these cells would proliferate quicker than naïve T-cells; ii) tumor antigens are presented by MHC class II molecules, which mostly stimulate Th1 or Th2 responses; while Tc1 cells are more likely to mediate cytotoxic anti tumor responses; iii) these cells are rather long living as it was determined in our previous paper [26]. The gene discussed is HLA-C; the disease is neoplasm.