In humans, polymorphisms in the encoded plama membrane selenoprotein (SEPS1, or SELS gene) correlate to diabetes mellitus and coronary heart diseases. The selenoprotein regulate red-ox balance and clear cells of misfolded proteins. Gene polymorphisms result in accumulation of these proteins even higher under cell stress. Carriers have higher IL1, -6, -10, and TNF [111]. Here, TNF is linked to diabetes mellitus.