Whole body insulin resistance in Dahl S rats was evidenced by a decrease in glucose utilization during the hyperinsulinemia-euglycemic clamp analysis while peripheral insulin resistance in Dahl S rats was evidenced by a decrease in insulin-stimulated 2 deoxy-glucose uptake by adipocytes and skeletal muscles obtained from high-salt-fed Dahl S versus Dahl R rats. The gene discussed is INS; the disease is hyperinsulinism.