Owing to the fact that high salt-fed Dahl S rats have augmented salt-induced oxidative stress in most tissues [9-12], and that oxidative stress generates mediators of inflammation such as NF-kappa B, TNF-α and JNK, known to disrupt the insulin signaling pathway, I chose to review the putative genetic variations in the markedly over-expressed genes along the inflammatory pathway (NF-kappa B, TNF-α and JNK) that might be predictive of insulin resistance in Dahl S rat model. The gene discussed is TNF; the disease is Insulin resistance.