ROS interfere with normal insulin signaling and precipitate insulin resistance via a number of mechanisms including: i) disruption of insulin-induced IRS-1 and PI3-kinase phosphorylation and cellular distribution, ii) reduction in GLUT4 expression levels, or iii) reduction in GLUT4 translocation to the plasma membrane [47-50]. The gene discussed is SLC2A4; the disease is Insulin resistance.