Variegate Porphyria (VP) (MIN # 176200) is an autosomal dominant disorder associated with a deficiency of the penultimate enzyme of the heme biosynthetic pathway [1-3] the Protoporphyrinogen oxidase [PPOX; EC 1.1.3.4, Genebank accession number X99450.1] which catalyses the six-electron conversion of Protoporphyrinogen IX to Protoporphyrin IX (PROTO IX) (Figure 1). The gene discussed is PPOX; the disease is porphyria.