Various compounds have beenreported to be PPAR antagonists, including Bisphenol A diglycidyl ether(BADGE), PD068235, LG100641, GW9662, SR-202, GW6741, and Compound A and B [83].A potent selective PPARγ antagonist,GW9662, does not recruit PPAR coactivators such as SRC-1 and p300, and itsuppresses rosiglitazone-induced adipocyte differentiation in 3T3-L1 adipocytes.GW9662 prevents high-fat diet-induced obesity without affecting food intake,and has no effect on high-fat diet-induced glucose intolerance [84]. This evidence concerns the gene PPARA and obesity due to melanocortin 4 receptor deficiency.