PPARA and Insulin resistance: We next planned todevelop a PPARα/δ-dual agonist, which would effectively activate both PPARα and PPARδ, because pharmacologicalevidence indicated that PPARα regulates theexpression of genes encoding proteins involved in lipid and lipoproteinhomeostasis, and subsequent pharmacological findings for PPARδ demonstrated that it also plays a key role inlipid metabolism and insulin resistance.