In the Dallas Heart Study, a population-based cohort of nearly 3400 subjects aged 30–65 years (19), higher CRP levels were associated with a modest increase in the prevalence of subclinical atherosclerosis as detected by electron-beam computed tomography (EBCT) or magnetic resonance imaging (MRI), but this association was not independent of traditional cardiovascular risk factors. The gene discussed is CRP; the disease is atherosclerosis.